40. RITHWIK RAMACHANDRAN
Information acquired: 2025
RITHWIK RAMACHANDRAN is an academic who published a paper in 2019 entitled Limiting Autoimmune Neuroinflammation using Novel T Cell Suppressants & Investigating Overlappin. RITHWIK RAMACHANDRAN published this work as part of a team: Ewanchuk, Benjamin Walter. Here is a description of this work: Abe,,rant activation of adaptive immune cells can culminate in autoimmune diseases such as multiple sclerosis (MS). Recently, potent anti-inflammatory properties for the cooling compound, icilin, and its receptor target, Transient Receptor Potential Melastatin-8 (TRPM8), were characterized in the context of inflammatory colitisâ€"the first half of this dissertation describes an attempt to repurpose the anti-inflammatory qualities of icilin and TRPM8 for the treatment of lymphocyte-mediated neuroinflammation. We found icilin treatment strongly attenuated experimental autoimmune encephalomyelitis (EAE), a murine model of MS, via an unexpected TRPM8-independent mechanism. Icilin inhibited the proliferation, polarization and downstream effector function of CD4 T cells, suggesting a promising drug for limiting neuroinflammation.