Locate family members with the last name RAMALHO-SANTOS.

J. Ramalho-Santos is an academic who published a paper in 2009-10-20 entitled Enhancement of Human Embryonic Stem Cell Pluripotency Through Inhibition of The Mitochondrial Respiratory Chain. The paper was published in a journal entitled Stem cell research.

JOAO RAMALHO-SANTOS is an academic.

João Ramalho-Santos is an academic who published a paper in 2020-07-20 entitled Insights from qualitative research on NAFLD awareness with a cohort of T2DM patients: time to go public with insulin resistance?. The paper was published in a journal entitled BMC Public Health.

Miguel Ramalho-Santos is an academic who published a paper in 2016-12-22 entitled Hypertranscription in development, stem cells, and regeneration. The paper was published in a journal entitled Developmental cell.

MIGUEL RAMALHO-SANTOS is an academic.

MIGUEL RAMALHO-SANTOS is an academic who published a paper in 2018 entitled Vitamin C induces specific demethylation of H3K9me2 in mouse embryonic stem cells via Kdm3a/b. MIGUEL RAMALHO-SANTOS published this work as part of a team: Ebata, Kevin T. Here is a description of this work: Bac,,ground: Histone methylation patterns regulate gene expression and are highly dynamic during development. The erasure of histone methylation is carried out by histone demethylase enzymes. We had previously shown that vitamin C enhances the activity of Tet enzymes in embryonic stem (ES) cells, leading to DNA demethylation and activation of germline genes. Results: We report here that vitamin C induces a remarkably specific demethylation of histone H3 lysine 9 dimethylation (H3K9me2) in naïve ES cells. Vitamin C treatment reduces global levels of H3K9me2, but not other histone methylation marks analyzed, as measured by western blot, immunofluorescence and mass spectrometry. Vitamin C leads to widespread loss of H3K9me2 at large chromosomal domains as well as gene promoters and repeat elements. Vitamin C-induced loss of H3K9me2 occurs rapidly within.