34. VARUNE-ROHAN RAMNARINE
Information acquired: 2025
VARUNE-ROHAN RAMNARINE is an academic who published a paper in 2019 entitled The long non-coding RNA landscape of neuroendocrine prostate cancer and its clinical implications, b. VARUNE-ROHAN RAMNARINE published this work as part of a team: Ramnarine, Varune Rohan. Here is a description of this work: Neuroendocrine prostate cancer (NEPC) is a lethal subtype of castration-resistant prostate cancer (CRPC). It can develop de novo from prostate neuroendocrine cells, yet primarily is a treatment-induced phenotype arising from transdifferentiated prostate adenocarcinoma (AD) cells (NEtD). Currently there is an unmet clinical need for predictive biomarkers, therapeutic targets, and more reliable diagnostics. In this dissertation we use the first-in-field patient-derived xenograft model of NEtD, six in vitro CRPC/NEPC models, and ~30,000 PCa patient samples, including 344 NEPC or molecular analogous NEPC samples. We implement a state-of-the-art next-generation sequence analysis pipeline, capable of detecting transcripts at low expression levels to build a comprehensive lncRNA catalog (~N=40,000). Our xenograft model enable.