3. ALFREDO RAMOS-MIGUEL ♂
Information acquired: 2025
ALFREDO RAMOS-MIGUEL is an academic who published a paper in 2017 entitled Loss of Munc18-1 long splice variant in GABAergic terminals is associated with cognitive decline and. ALFREDO RAMOS-MIGUEL published this work as part of a team: Ramos-Miguel, Alfredo. Here is a description of this work: Bac,,ground: Presynaptic terminals contribute to cognitive reserve, balancing the effects of age-related pathologies on cognitive function in the elderly. The presynaptic protein Munc18-1, alternatively spliced into long (M18L) or short (M18S) isoforms, is a critical modulator of neurotransmission. While subtle alterations in Munc18-1 have been shown to cause severe neuropsychiatric disorders with cognitive impairment, little information is known regarding the specific roles of Munc18-1 splice variants. We first investigated functional and anatomical features evidencing the divergent roles of M18L and M18S, and then evaluated their contribution to the full range of age-related cognitive impairment in the dorsolateral prefrontal cortex of a large sample of participants from a community-based aging study, including subjects with no, (NCI,.