28. TIM RAMSAY ♂
Information acquired: 2025
TIM RAMSAY is an academic who published a paper in 2009 entitled Stopping randomized trials early for benefit: a protocol of the Study Of Trial Policy Of Interim Tru. TIM RAMSAY published this work as part of a team: Briel, Matthias. Here is a description of this work: Background: Randomized clinical trials (RCTs) stopped early for benefit often receive great attention and affect clinical practice, but pose interpretational challenges for clinicians, researchers, and policy makers. Because the decision to stop the trial may arise from catching the treatment effect at a random high, truncated RCTs (tRCTs) may overestimate the true treatment effect. The Study Of Trial Policy Of Interim Truncation (STOPIT-1), which systematically reviewed the epidemiology and reporting quality of tRCTs, found that such trials are becoming more common, but that reporting of stopping rules and decisions were often deficient. Most importantly, treatment effects were often implausibly large and inversely related to the number of the events accrued. The aim of STOPIT-2 is to determine the magnitude and determinants of possi.