13. ANDREW-H RAMSOOK
Information acquired: 2025
ANDREW-H RAMSOOK is an academic who published a paper in 2020 entitled Sho,,t-term effects of Lumacaftor/Ivacaftor (Orkambiâ"¢) on exertional symptoms, exercise perfo. ANDREW-H RAMSOOK published this work as part of a team: Quon, Bradley S. Here is a description of this work: Rat,,onale: Lumacaftor/ivacaftor (LUM/IVA) modestly improves lung function following 1 month of treatment but it is unknown if this translates into improvements in exercise endurance and exertional symptoms. Methods: Adult CF participants completed a symptom-limited constant load cycling test with simultaneous assessments of dyspnea and leg discomfort ratings pre, and 1 month post-initiation of LUM/IVA. Results: Endurance time, exertional dyspnea and leg discomfort ratings at submaximal exercise did not change significantly. There was a significant inverse correlation between changes in leg discomfort and endurance time (r = âˆ' 0. 88, p = 0. 009) following 1-month of LUM/IVA. Conclusions: Overall, 1-month of LUM/IVA did not increase endurance time or modify exertional dyspnea or leg discomfort ratings. However, individuals who experienced a.