29. ADAM-REHIM RAMZY
Information acquired: 2025
ADAM-REHIM RAMZY is an academic who published a paper in 2019 entitled Removing, replacing, and processing proinsulin in beta-cells. ADAM-REHIM RAMZY published this work as part of a team: Ramzy, Adam Rehim. Here is a description of this work: Dia,,etes affects over 425 million worldwide, costs billions, and causes morbidity and mortality for patients. Though insulin injections are lifesaving, insufficient β-cell mass and function leaves patients facing risks of chronic hyperglycemia and acute risks of hypoglycemia. Replacement of β-cells via transplantation of cadaveric islets is a functional cure but is limited by a paucity of donor tissue. If β-cell replacement or (re) generation therapies were abundantly available, they could be potential cures for diabetes. To this end, investigating β-cell development and function is worthwhile. In the current thesis, we first characterized the role of insulin on β-cell development and maturation by studying insulin knockout mice (Ins1-/-Ins2-/-). Though insulin was necessary for β-cell maturation, insulin replacement by islet transplantation but not insulin.